While there are multiple tumor types where GAS6/AXL signaling has been implicated, we are initially evaluating AVB-500 in platinum resistant ovarian cancer. Ovarian cancer is the most deadly reproductive cancer in women, and more than 22,000 women are diagnosed with the disease each year in the U.S. This cancer mainly develops in older women. Many women with advanced ovarian cancer who receive standard-of-care ultimately relapse and develop drug-resistant disease. We are focused on addressing the high unmet need in this patient population and are currently enrolling the Phase 1b portion of our Phase 1b/2 clinical trial in patients with platinum resistant ovarian cancer (NCT03639246). We plan to initiate our next Phase 1b/Phase 2 clinical trial of AVB-500 in patients with clear cell renal cell carcinoma and have received IND clearance (NCT04300140). In the future we hope to evaluate AVB-500 in combination with standard of care in a number of additional tumor types, including acute myeloid leukemia, triple negative breast cancer and pancreatic cancer.